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Mercedes-Benz S-Class W221

Mercedes-Benz S-Class W221 (November 2005 – November 2012) has 6 published engines in the catalogue, and 930 cars in our dataset. Engine ranges cover the trims and gearboxes stored for that engine.

Engines

Combined mpg and CO₂ are the ranges stored for the engine. The official test cycle is shown on each variant.

EngineFuelPowerCombined mpg rangeCO₂ rangeDataset
3.0 diesel 234PSDiesel234.2 PS33.6–34 mpg225–228 g/km335
3.0 diesel 238PSDiesel238.3 PS36.7–37.2 mpg201–204 g/km74
3.0 diesel 262PSDiesel261.6 PS41.5 mpg168 g/km307
3.5 petrol 276PSPetrol275.8 PS28 mpg247 g/km42
5.5 petrol 388PSPetrol387.6 PS23.9–24.1 mpg283–286 g/km81
5.5 petrol 517PSPetrol516.7 PS20 mpg340 g/km21

Trims

Trim names stored for this generation.

  • S320 Cdi
  • S320L Cdi
  • S350
  • S350 Bluetec
  • S350 Bluetec L
  • S350 Bluetec L Amg Sport Edition
  • S350 Cdi Blueefficiency
  • S350 Cdi Blueefficiency L
  • S350L
  • S500
  • S500L
  • S600L

Variants

Filters apply to the published variants. The engine and trim lists above stay in the page HTML.

VariantFuelGearboxBodyPowerCombined mpgDataset
S320 Cdi 3.0 diesel 234PSDieselAutomaticSaloon234.2 PS (231 bhp)34 mpg (NEDC)253
S320L Cdi 3.0 diesel 234PSDieselAutomaticSaloon234.2 PS (231 bhp)33.6 mpg (NEDC)82
S350 Cdi Blueefficiency 3.0 diesel 238PSDieselAutomaticSaloon238.3 PS (235 bhp)37.2 mpg (NEDC)43
S350 Cdi Blueefficiency L 3.0 diesel 238PSDieselAutomaticSaloon238.3 PS (235 bhp)36.7 mpg (NEDC)31
S350 Bluetec 3.0 diesel 262PSDieselAutomaticSaloon261.6 PS (258 bhp)41.5 mpg (NEDC)144
S350 Bluetec L Amg Sport Edition 3.0 diesel 262PSDieselAutomaticSaloon261.6 PS (258 bhp)41.5 mpg (NEDC)32
S350 Bluetec L 3.0 diesel 262PSDieselAutomaticSaloon261.6 PS (258 bhp)41.5 mpg (NEDC)131
S350 3.5 petrol 276PSPetrolAutomaticSaloon275.8 PS (272 bhp)28 mpg (NEDC)22
S350L 3.5 petrol 276PSPetrolAutomaticSaloon275.8 PS (272 bhp)28 mpg (NEDC)20
S500 5.5 petrol 388PSPetrolAutomaticSaloon387.6 PS (382.2 bhp)24.1 mpg (NEDC)21
S500L 5.5 petrol 388PSPetrolAutomaticSaloon387.6 PS (382.2 bhp)23.9 mpg (NEDC)60
S600L 5.5 petrol 517PSPetrolAutomaticSaloon516.7 PS (509.6 bhp)20 mpg (NEDC)21
12 variants

Specifications

Recorded dates
November 2005 – November 2012
Engines
6
Power
234.2–516.7 PS
Fuels
Diesel, Petrol
Gearboxes
Automatic
Body styles
Saloon
UK dataset
930 cars in our dataset

Performance

Highest power

Published variants in this generation with a stored PS figure, highest first.

Bar length is the stored PS figure. Brake horsepower is a different unit and is not plotted here.
VariantPowerGearboxBody
S600L 5.5 petrol 517PS516.7 PS (509.6 bhp)AutomaticSaloon
S500 5.5 petrol 388PS387.6 PS (382.2 bhp)AutomaticSaloon
S500L 5.5 petrol 388PS387.6 PS (382.2 bhp)AutomaticSaloon
S350L 3.5 petrol 276PS275.8 PS (272 bhp)AutomaticSaloon
S350 3.5 petrol 276PS275.8 PS (272 bhp)AutomaticSaloon

Fastest 0–60

Published variants with a stored 0–60 time, quickest first.

Bar length is the stored 0–60 time. A longer bar is a slower time.
Variant0–60 mphGearboxBody
S600L 5.5 petrol 517PS4.6 secondsAutomaticSaloon
S500L 5.5 petrol 388PS5.4 secondsAutomaticSaloon
S500 5.5 petrol 388PS5.4 secondsAutomaticSaloon
S350 Bluetec L 3.0 diesel 262PS7.1 secondsAutomaticSaloon
S350 Bluetec 3.0 diesel 262PS7.1 secondsAutomaticSaloon

Fuel economy

NEDC combined mpg

These variants share the NEDC test. They are not compared with figures from another cycle.

Combined mpg on the NEDC test only. A different official cycle is not on this chart.
VariantCombinedCO₂Fuel
S350 Bluetec 3.0 diesel 262PS41.5 mpg (NEDC)168 g/kmDiesel
S350 Bluetec L Amg Sport Edition 3.0 diesel 262PS41.5 mpg (NEDC)168 g/kmDiesel
S350 Bluetec L 3.0 diesel 262PS41.5 mpg (NEDC)168 g/kmDiesel
S350 Cdi Blueefficiency 3.0 diesel 238PS37.2 mpg (NEDC)201 g/kmDiesel
S350 Cdi Blueefficiency L 3.0 diesel 238PS36.7 mpg (NEDC)204 g/kmDiesel
S320 Cdi 3.0 diesel 234PS34 mpg (NEDC)225 g/kmDiesel
S320L Cdi 3.0 diesel 234PS33.6 mpg (NEDC)228 g/kmDiesel
S350 3.5 petrol 276PS28 mpg (NEDC)247 g/kmPetrol
S350L 3.5 petrol 276PS28 mpg (NEDC)247 g/kmPetrol
S500 5.5 petrol 388PS24.1 mpg (NEDC)283 g/kmPetrol
S500L 5.5 petrol 388PS23.9 mpg (NEDC)286 g/kmPetrol
S600L 5.5 petrol 517PS20 mpg (NEDC)340 g/kmPetrol

Registration statistics

930 cars in our dataset. Shares below are calculated inside that dataset.

Fuel type

  • Diesel716 · 77%
  • Petrol214 · 23%
Counted inside this dataset. The shares are not UK sales.

Body style

  • Saloon930 · 100%
Counted inside this dataset. The shares are not UK sales.

Transmission

  • Automatic930 · 100%
Counted inside this dataset. The shares are not UK sales.

Colour

  • Black373 · 40.1%
  • Silver372 · 40%
  • Grey80 · 8.6%
  • Blue46 · 4.9%
  • White22 · 2.4%
  • Red15 · 1.6%
  • Other22 · 2.4%
Counted inside this dataset. The shares are not UK sales.

Registration year

  • 1202006
  • 1642007
  • 992008
  • 1022009
  • 1152010
  • 1062011
  • 1402012
  • 662013
Cars in the VehicleScore dataset by registration year. This is not a sales chart.

Other generations

W126
  • Recorded datesFebruary 1986 – August 1992
  • Dataset198 cars in our dataset
W140
  • Recorded datesJanuary 1991 – March 2001
  • Dataset76 cars in our dataset
V220
  • Recorded datesMarch 1998 – November 2018
  • Dataset94 cars in our dataset
W220
  • Recorded datesJanuary 1999 – June 2006
  • Dataset210 cars in our dataset
S-Class (W222)
  • Recorded datesJune 2013 – October 2022
  • Dataset1,537 cars in our dataset
W223
  • Recorded datesSeptember 2020 – Present
  • Dataset130 cars in our dataset

Length, width, height, and wheelbase are listed on each variant page, where the catalogue stores them for one configuration.

Related VehicleScore tools

Check your Mercedes-Benz S-Class W221

Enter a UK registration to check a Mercedes-Benz S-Class W221. This page describes that generation, not one number plate.

Questions

Which engines are listed for the Mercedes-Benz S-Class W221?

3.0 diesel 234PS, 3.0 diesel 238PS, 3.0 diesel 262PS, 3.5 petrol 276PS, 5.5 petrol 388PS, 5.5 petrol 517PS

How many Mercedes-Benz S-Class W221 cars are in the dataset?

930 cars in our dataset. Registration-year, fuel, body, and gearbox shares on this page are counted inside that sample.

How these figures are produced

Specifications and counts come from the VehicleScore UK vehicle catalogue. A count of cars is the number of records in that dataset. It is not UK production, not sales, and not the number of cars currently on the road.

Power is shown in PS where the catalogue stores PS, and in bhp only where bhp is stored separately. Official fuel economy is labelled NEDC or WLTP when the test cycle is known. Figures from different cycles are not ranked together. Empty values are left blank.

The catalogue does not store a revision date, so these pages do not show a last-updated day.